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Infantile Chronic Necrotizing Encephalopathy 1
Author(s) -
CHRISTENSEN ERNA,
MELCHIOR J. C.,
PLUM P.
Publication year - 1963
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1963.tb03783.x
Subject(s) - medicine , autopsy , etiology , pons , medulla oblongata , encephalopathy , spinal cord , girl , pathology , medulla , pediatrics , central nervous system , anatomy , developmental psychology , psychiatry , psychology
SUMMARY The clinical history and brain autopsy are presented of a girl who from the age of 2–3 years showed progressing neurological symptoms lasting 10 years with short periods of improvement. The clinical picture was one of mixed pyramidal and extrapyramidal signs, of speech difficulties, but well preserved mental abilities. At autopsy symmetrical lesions were found, involving the putamina and the caudate nuclei, also affecting the pons and medulla oblongata and spinal cord, being of younger age caudally in the central nervous system. The close resemblance of a case previously reported by us in 1956 is striking. Our two cases give no conclusive information with regard to the etiology and pathogenesis. Regarding classification, it is possible that we are dealing with a disorder representing a chronic form of infantile necrotizing encephalopathy comparable to a subacute form described by Richter. among others, and perhaps it is also comparable to an acute form described by Verhaart.