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Intragastric Oxygen: Experimental Observations in Newborn Puppies 1
Author(s) -
JAMES L. S.,
APGAR V. A.,
MOYA F.,
KVISSELGAARD N.,
BURNARD E. D.,
BRADY J.,
TUCHMAN W.,
CRAWFORD J. S.,
HOLADAY D. A.
Publication year - 1963
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1963.tb03776.x
Subject(s) - medicine , anesthesia , oxygen , resuscitation , ductus arteriosus , ductus venosus , stomach , surgery , fetus , pregnancy , chemistry , organic chemistry , biology , genetics
SUMMARY Ten puppies delivered by cesarean section and paralysed with succinylcholine were given intragastric oxygen. There was no evidence of oxygen absorption from the stomach or gut as judged by the oxygen saturation of the portal vein or aortic blood. However, when the lungs were expanded and artificial ventilation applied, the oxygen levels rose rapidly. The pH fell and the PCO 2 rose during asphyxiation at approximately the same rate in both the experimental group and a control group, irrespective of the administration of I.G. O 2 . The useof I.G. O 2 was completely ineffective as a resuscitation procedure even though the oxygen requirements were minimized by paralysing the animals, and the ductus venosus, foramen ovale and ductus arteriosus were patent.