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ACTH‐Induced Thymic Atrophy
Author(s) -
BJÖRKLUND STIGIVAR
Publication year - 1961
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1961.tb08204.x
Subject(s) - medicine , mediastinum , ganglioneuroma , atrophy , radiology , pathology , neuroblastoma , biology , genetics , cell culture
Summary In 13 cases with a widening of the mediastinum, discovered in the course of roentgenologic examination, ACTH was administered to increase the possibilities of diagnosing the cause. In 11 cases there was a reduction of the width of the mediastinum. The decrease is considered to be due to the thymolytic effect of the adreno‐corticosteroids. In one case the widening remained unchanged; in this case entirely too small a dose of ACTH was given. In another case the more circumscribed enlargement remained unchanged and the subsequent operation revealed that it was composed of a ganglioneuroma.