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Studies of the Immunological Relationship between the Antigens from Different Organs in Human Ulcerative Colitis 1
Author(s) -
BROBERGER OVE
Publication year - 1961
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1961.tb08048.x
Subject(s) - ulcerative colitis , antigen , medicine , kidney , hemagglutination , antibody , colitis , immunology , pathology , disease
Summary Sera from children with ulcerative colitis haemagglutinate sheep red blood cells coated with phenol‐water extracts of human colon, liver or kidney. It was found that the haemagglutination of colon‐coated cells could be completely or partially inhibited by previous absorption of the sera with extracts of colon, liver or kidney. Likewise, the haemagglutination of liver‐coated cells could be inhibited by means of extract from colon or liver. The results indicate that liver and colon contain at least one immunologically identical or similar antigen. In addition, certain preliminary results suggest that the sera contain antibodies against several distinct antigens, some of which are present only in the extracts of colon and not in those of liver or kidney.