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Myocardial Changes Following Oxygen Inhalation An Experimental Study on Rabbits
Author(s) -
BERFENSTAM R.,
ZETTERGREN L.
Publication year - 1959
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1959.tb05413.x
Subject(s) - medicine , inhalation , ventricle , hypoxia (environmental) , myocarditis , edema , pathology , oxygen , tissue hypoxia , pulmonary edema , anesthesia , cardiology , physiology , lung , oxygenation , chemistry , organic chemistry
Summary A variety of myocardial changes, predominantly in the left ventricle, were observed in 38 of 46 rabbits which were exposed to 70 to 80 per cent oxygen until they died. In the majority of animals the changes took the form of vacuolar degeneration, altered stainability of the muscular tissue and interstitial edema. In addition, the animals exhibited major structural changes leading to myolysis and development of myocarditis‐like foci. It is the authors' contention that the changes in question are secondary to such pulmonary lesions as are caused by oxygen inhalation and, hence, that at least partially they are caused by hypoxia.