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Tetracycline Treatment of Whooping‐Cough
Author(s) -
JERNELIUS HANS
Publication year - 1956
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1956.tb06910.x
Subject(s) - medicine , whooping cough , tetracycline , placebo , incidence (geometry) , surgery , pediatrics , antibiotics , immunology , physics , alternative medicine , optics , pathology , biology , microbiology and biotechnology , vaccination
Summary Fifty‐four cases of whooping‐cough were treated with tetracycline (Tetracyn). In 42 cases, serving as controls, a placebo was given. The dosage was 30 mg/kg body weight daily, divided into 4 doses. The course of the drug was started 4 days after admission and continued for 7 days. The effect of the treatment was assessed by the number of paroxysms and “whoops”. The material was divided into two groups, one including cases where symptoms had been present for less than a fortnight prior to admission, and one with symptoms since more than a fortnight. In neither group was any effect of the Tetracyn treatment to be demonstrated. All but 2 of the treated cases were free of bacilli after termination of treatment. The incidence rates of complications were the same in the treated and control series. The treatment gave rise to few untoward effects. Transient diarrhoea occurred in 14%. 54 cas de Coqueluche ont été traité par la tétracycline (Tétracyn), et par comparaison, un groupe témoin de 42 cas reçut un placebo. La dose administrée fut de 30 mg/kg de poids, en 4 prises quotidiennes. Le médicament fut donné 4 jours aprhs l'entrde, et pendant 7 jours. Aucun effet bénéfique ne fut enregistré, quelque soit le moment où le traitement fut commencé. Dans 14% des cas, une diarrhée passagère fut observée.