Premium
Folic Acid Antagonists and ACTH in the Treatment of Leucemia in Children.
Author(s) -
FOGHTNIELSEN K.E.,
FRIISHANSEN B.,
PLUM M.
Publication year - 1954
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1954.tb15478.x
Subject(s) - medicine , folic acid , dose , pediatrics , complete remission , disease , prednisone , surgery , chemotherapy
Summary By treatment of 22 children with acute leucemia by ACTH and/or folic acid antagonists, complete and partial remissions have been obtained in 13 patients, in a total number of 32. The average survival time of all these 22 patients is 7 months, and that of the 13 who got remissions, 10 months. Twenty‐two patients from an earlier period survived 4 months on an average. The best results have been obtained by alternating treatment by ACTH initially and at relapses and a‐methopterin in maintenance dosages during the remissions. The burden and painfulness of the disease seem to be relieved by the treatment even if the final result is unaltered.