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Congenital Idiopathic Hypoprothrombinemia 1
Author(s) -
CREVELD S. VAN
Publication year - 1954
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1954.tb15475.x
Subject(s) - hypoprothrombinemia , medicine , thromboplastin , prothrombin complex , prothrombin time , pediatrics , partial thromboplastin time , coagulation , vitamin k
Summary Attention is drawn to the fact that a prolongation of the prothrombin time existing from birth may be due to a decrease of prothrombin, to a decrease of the recently described prothrombin conversion factors, and to a combination of both. Therefore, apart from true hypoprothrombinemia, pseudo‐hypo‐prothrombinemia must be distinguished. These advances in our knowledge make it necessary to reconsider cases earlier indicated as congenital idiopathic hypoprothrombinemia. A family with true congenital idiopathic, hypoprothrombinemia is described in detail. With the plasma of one of the members of this family the problem of the formation of thromboplastin was studied.