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A Case of Vitamin D Resistant Rickets Treated with Massive Doses of Vitamin D 2
Author(s) -
CARLGREN LARSERIK
Publication year - 1948
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1948.tb03751.x
Subject(s) - rickets , medicine , citric acid , vitamin d and neurology , vitamin , endocrinology , phosphorus , alkaline phosphatase , biochemistry , enzyme , biology , chemistry , organic chemistry
SUMMARY A case of rickets resistant to ordinary vitamin D therapy is described. A familiar factor has, in all likelihood, played a part in the pathogenesis. Treatment with citric acid‐sodium citrate was of no benefit which agrees with the experience of B utler . Massive daily doses of vitamin D, given by mouth in periods of ten to fourteen days had a marked effect on the blood phosphorus and plasma phosphatase concentrations and brought about a conspiciuous healing of the skeletal changes as seen in the X‐ray (see Figs 2 and 3). No toxic reactions to these large doses of vitamin D were seen.