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Familial Haemorrhagic Diatheses with Prolonged Bleeding‐Time (Thrombopathias)
Author(s) -
IMERSLUND OLGA
Publication year - 1947
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1947.tb03709.x
Subject(s) - medicine , bleed , hemorrhagic diathesis , platelet , purpura (gastropod) , bleeding time , diathesis , bleeding diathesis , pediatrics , prothrombin time , surgery , immunology , platelet aggregation , ecology , biology
SUMMARY The author has investigated the familial occurence of haemor‐rhagic diatheses with prolongation of the bleeding‐time in three families. The number of thrombocytes was, as a rule, normal. Throni‐bopenia (with the number of thrombocytes as far down as to 8 300) was observed at certain of the examinations. Diminution of clot‐retraction was also observed in some of the cases even when the number of thrombocytes was normal. In the second family a maternal aunt of children suffering from haemorrhagic diathesis with prolongation of bleeding‐time, developed transitory thrombopenic purpura at the age of 26 as a sequel to an attack of acute hepatitis. She showed no tendency to bleed excessively either before or after this event. In the other cases there was no relationship between the number of thrombocytes and the tendency to bleed, and the thrombocytes showed no important departures from the normal. The coagulation‐time and the prothrombin‐time were normal. The fact that several patients were the offspring of parents who were related to each other and who showed no signs of a haemorrhagic diathesis is suggestive of a recessive inheritance.