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On the Relationship between Prothrombin Time and Haematocrit Value
Author(s) -
MELIN GUNNEL
Publication year - 1945
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1945.tb16852.x
Subject(s) - medicine , prothrombin time , oxalate , endocrinology , chemistry , organic chemistry
Summary. By removal of plasma from oxalate blood, as well as addition of plasma to it in one and the same person, the author has produced a dilution series of blood corpuscles‐plasma, in other words, a series of blood tests with different haematocrit values. The prothrombin time has been determined on these samples by means of Fiechter's method. It has then been found that a comparatively slight prolongation of the prothrombin time at increasing haematocrit values has taken place in the blood of healthy individuals. When, on the other hand, the prothrombin content in the blood has for some reason or other been reduced, the prothrombin time at increasing haematocrit values has undergone a palpable prolongation. Therefore, when a deficiency in prothrombin is suspected, the haematocrit values of those concerned must be taken into consideration. This should especially be born in mind in comparisons between the prothrombin times of infants. When a possible prothrombin deficiency is suspected and no distinct prolongation of the prothrombin time has been determined at the ordinary examination a plasma dilution may give the information required.