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Occurrence and Significance of Early Periosteal Proliferation in the Diaphyses of Premature Infants
Author(s) -
MALMBERG NILS
Publication year - 1945
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1945.tb16850.x
Subject(s) - rickets , medicine , epiphysis , diaphysis , tibia , sign (mathematics) , pediatrics , femur , endocrinology , vitamin d and neurology , anatomy , surgery , mathematical analysis , mathematics
Summary. The majority of prematurely born infants show at an early age, 4–6 weeks, at a stage when there are no signs of rickets at the epiphysis, a greater or lesser degree of periosteal proliferation at the diaphysis of the long bones, especially of the tibia. Reasons are advanced to support the view that this pathologic feature is a sign of vitamin D deficiency and is to be regarded as the earliest roentgenologic evidence of rickets, often appearing 4–6 weeks before the epiphyseal changes.