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Cell‐based therapies for epidermolysis bullosa – from bench to bedside
Author(s) -
Uitto Jouni,
Has Cristina,
BrucknerTuderman Leena
Publication year - 2012
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2012.08035.x
Subject(s) - epidermolysis bullosa , bench to bedside , medicine , clinical trial , dermatology , bioinformatics , pathology , medical physics , biology
Summary Significant progress has been made over the past two decades in molecular genetics of epidermolysis bullosa (EB), a group of heritable blistering disorders, with diagnostic and prognostic implications. More recently, novel molecular approaches have been developed towards potential treatment of EB, with emphasis on gene‐, protein‐, and cell‐based strategies. This overview highlights cell‐based approaches that have recently been tested in pilot clinical trials, attesting to the potential of regenerative medicine for blistering skin diseases.