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Primary cutaneous B‐cell lymphomas
Author(s) -
Kempf Werner,
Denisjuk Natalja,
Kerl Katrin,
Cozzio Antonio,
Sander Christian
Publication year - 2012
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2011.07852.x
Subject(s) - cbcl , lymphoma , medicine , pathology , marginal zone , cutaneous lymphoma , immunohistochemistry , large cell , histology , b cell , antibody , cancer , immunology , adenocarcinoma , mycosis fungoides , clinical psychology
Summary Cutaneous B‐cell lymphomas (CBCL) are the second most common form of primary cutaneous lymphomas. The cutaneous follicle center lymphoma and the cutaneous marginal zone lymphoma (extranodal MALT type lymphoma) account for the vast majority of CBCL and manifest with nodules. These two lymphoma entities have an indolent, slowly progressive course and an excellent prognosis despite a high rate of recurrences. In contrast, cutaneous diffuse large B‐cell lymphoma, leg type, and other rare forms of CBCL display an impaired prognosis and therefore require to be treated with multiagent chemotherapy and anti‐CD20 monoclonal antibodies in most cases. Clinico‐pathologic correlation, histology with immunohistochemical profile and genotyping as well as staging examinations are crucial diagnostic elements in the work‐up of CBCL.