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Indocyanine green fluorescence‐guided sentinel lymph node biopsy in dermato‐oncology
Author(s) -
Stoffels Ingo,
von der Stück Hannah,
Boy Christian,
Pöppel Thorsten,
Körber Nina,
Weindorf Maren,
Dissemond Joachim,
Schadendorf Dirk,
Klode Joachim
Publication year - 2012
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2011.07843.x
Subject(s) - indocyanine green , sentinel lymph node , medicine , biopsy , lymphatic system , radiology , melanoma , lymph , pathology , cancer , breast cancer , cancer research
Summary Background: Sentinel lymph node biopsy (SLNB) for cutaneous malignancies usually carried out with radioactive nanocolloids (Tc‐99m). The SLNE is controversially discussed internationally. This is especially given to the high false‐negative rate up to 44 %. An alternative could be the fluorescent dye indocyanine green (ICG). Material and Methods: We investigated the advantage of intraoperative fluorescence detection of lymphatic vessels and SLN with a Near‐Infrared (NIR) camera in comparison to conventional methods using preoperative lymphoscintigraphy and SPECT/CT in 22 patients with malignant melanoma. Results: A total of 61 SLNs were removed in 22 operative procedures. In 7 SLN (10.3 %; 7/68) the histopathological assessment could demonstrate a metasta‐tic involvement. 11 additional SLN (19.1 %) in 8 patients were only identified using the fluorescent labeling. Two of these additional SLN (9.1 %; 2/22) showed metastatic involvement. Conclusion: The ICG fluorescence‐guided SLNB is an innovative imaging technique for dermato‐oncology, reliable and providing additional information in the detection of SLN. Therefore SLNB with fluorescence‐dye is an attractive option with intraoperative real‐time lymphoscintigraphy to improve the detection of SLN in cutaneous malignancies and potential reduction of the false negative rate in SLN.