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Immediate and delayed hypersensitivity to corticosteroids
Author(s) -
Basedow Sarah,
Eigelshoven Sibylle,
Homey Bernhard
Publication year - 2011
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2011.07718.x
Subject(s) - medicine , dermatology , allergy , anaphylaxis , hypersensitivity reaction , contact dermatitis , intensive care medicine , immunology
Summary Corticosteroids are therapeutic agents used in cases of allergy and intolerance. Due to the antiinflammatory effects of the corticosteroids, hypersensitivity reactions often are considered to be a paradox. However, delayed‐type reaction to corticosteroids is a frequent phenomenon in the daily routine. Non‐responding eczema, development of subacute contact eczema, systemic contact dermatitis or maculopapular exanthemas can be a clinical symptom of a delayed‐type hypersensitivity reaction to corticosteroids. Immediate‐type hypersensitivity reactions to corticosteroids remain uncommon. Nevertheless, they can take a severe clinical course. Patients react with anaphylaxis after systemic administration or with aggravation of an allergic reaction under therapy with corticosteroids. Allergologic testing is necessary for diagnosis and providing alternative corticosteroids in case of an emergency.