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Pathogenesis of Mycosis fungoides
Author(s) -
Beyer Marc,
Möbs Markus,
Humme Daniel,
Sterry Wolfram
Publication year - 2011
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2011.07635.x
Subject(s) - mycosis fungoides , pathogenesis , peripheral t cell lymphoma , homing (biology) , effector , phenotype , biology , pathology , medicine , immunology , dermatology , lymphoma , t cell , immune system , genetics , gene , ecology
Summary Mycosis fungoides is the most common type of primary cutaneous lymphomas. The phenotype of the tumor cell corresponds to an effector/memory‐type of helper T cell which, given its repertoire of homing receptors, is specialized for recirculation through the skin. In recent years genetic analyses have uncovered various chromosomal aberrations in the tumour cells of mycosis fungoides. Their relevance to the pathogenesis and clinical appearance are discussed in the following.