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Malignant melanoma during treatment with fumaric acid esters – coincidence or treatment‐related?
Author(s) -
Barth Dietrich,
Simon Jan C.,
Wetzig Tino
Publication year - 2011
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2010.07479.x
Subject(s) - psoriasis , melanoma , medicine , fumaric acid , malignancy , dermatology , disease , oncology , cancer research , chemistry , biochemistry
Summary Psoriasis is today generally considered a systemic disease. Systemic therapies are used frequently. In Germany fumaric acid esters – FAE (Fumaderm ® ) – are employed in more than 50 % of the patients requiring such therapy. We report for the first time the development of melanoma in two patients during their treatment with FAE. The logical question is – are the tumors coincidental or might they be treatment‐related? Further investigations of pathways and immunologic effects as well as careful reports of side effects are necessary to estimate the risks of malignancy of FAE.