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Penicillin and vitamin A as possible therapeutic agents in pityriasis rubra pilaris
Author(s) -
Popova Ludmila,
Darlenski Razvigor,
Tsankov Nikolai
Publication year - 2010
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2009.07290.x
Subject(s) - pityriasis rubra pilaris , medicine , erythroderma , penicillin , dermatology , antibiotics , methotrexate , systemic antibiotics , intramuscular injection , surgery , microbiology and biotechnology , biology , psoriasis
Summary Pityriasis rubra pilaris (PRP) is a rare skin disorder with versatile clinical presentations. A 62‐year‐old Caucasian woman with progressive erythroderma and classic adult (type I) PRP is presented. Treatment with systemic steroids and methotrexate produced no improvement. Clinical remission was achieved after systemic therapy with penicillin (both intravenous and intramuscular) and vitamin A. The therapy of PRP is reviewed, focusing on a possible infectious genesis of PRP as well as the role of antibiotics in its management.