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Photopheresis in pediatric patients with low‐body weight using the UVAR ® XTS™ system
Author(s) -
Hillen Uwe,
Meyer Sabine,
Schadendorf Dirk,
Kremens Bernhard
Publication year - 2010
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2009.07212.x
Subject(s) - extracorporeal photopheresis , medicine , photopheresis , body weight , saline , surgery , anesthesia , disease , graft versus host disease
Summary Background: Photopheresis (ECP) with the UVAR ® XTS™ system has been limited to patients with a body weight > 40 kg, because extracorporeal blood volumes (ECV) may exceed 15% of the total blood volumes in low‐body‐weight patients. Because of these instrument characteristics, the use of ECP is limited in pediatric patients. Patients and methods: In 5 patients (age 4 to 15 years) with graft‐versus‐host disease and with a body weight between 13 and 34 kilograms, photopheresis was performed using the UVAR ® XTS™ system. In 3 patients ECP could be performed by balancing the ECV with saline infusions. In 2 patients the system was modified in that the instrument was primed with packed red cells. During the treatment, fluid balance was guaranteed by a reservoir from a transfusion bag connected in parallel. Results: Together 223 procedures were performed, among them 28 with the modification of the system. The treatments were well tolerated, and no episodes of hypotension were observed. Conclusions: It is possible to run ECP in low‐body weight patients with the UVAR ® XTS™ system.