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Psoriasis – a systemic inflammatory disorder: clinic, pathogenesis and therapeutic perspectives
Author(s) -
Boehncke WolfHenning,
Sterry Wolfram
Publication year - 2009
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2009.07083.x
Subject(s) - psoriasis , comorbidity , medicine , insulin resistance , endothelial dysfunction , intensive care medicine , epidemiology , pathogenesis , dermatology , diabetes mellitus , bioinformatics , immunology , psychiatry , pathology , biology , endocrinology
Summary Psoriasis has seen a dramatic change in its perception by dermatologists as well as other medical specialties. Its well‐recognized association with several other diseases makes a complete switch in its management necessary. This review summarizes current epidemiological data on the comorbidities of psoriasis. Subsequently, the evidence for insulin resistance as a cause for endothelial cell dysfunction with its relevant pathogenetic link to the development of cardiovascular comorbidity is discussed. Based on these novel insights, we propose a possible state‐of‐the‐art approach towards comprehensive psoriasis management.