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HIV‐associated Kaposi sarcoma: pathogenesis and therapy
Author(s) -
Potthoff Anja,
Brockmeyer Norbert H.
Publication year - 2007
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2007.06567.x
Subject(s) - sarcoma , pathogenesis , medicine , cryosurgery , alpha interferon , kaposi's sarcoma , radiation therapy , cancer research , cryotherapy , interferon , immunology , dermatology , pathology , human herpesvirus , surgery
Summary While classical Kaposi sarcoma is a slowly progressing tumor, AIDS‐related Kaposi sarcoma is much more aggressive. After introduction of antiretroviral therapy and with the use of well‐ tolerated chemotherapeutic agents, complete remission of the tumor can be achieved. Local therapeutic options include excision,cryosurgery,radiation and alitretinoin gel.In 45 % of patients with more than 400/μl CD4+ lymphocytes,interferon‐alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis.