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Wegener's granulomatosis presenting as pyoderma gangrenosum
Author(s) -
Boudny Clara,
Nievergelt Helga,
Braathen Lasse R.,
Simon Dagmar
Publication year - 2008
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2007.06497.x
Subject(s) - pyoderma gangrenosum , medicine , proteinase 3 , vasculitis , differential diagnosis , anti neutrophil cytoplasmic antibody , biopsy , dermatology , skin biopsy , skin ulcer , pathology , disease
Summary Half of the patients with Wegener's granulomatosis develop skin lesions due to the systemic vasculitis. Wegener's granulomatosis should be included in the differential diagnostic considerations for necrotic ulcers, including leg ulcers. We present a case which demonstrates the importance of histological evaluation of a skin biopsy from the margin of the ulcer for establishing the diagnosis. Antineutrophil cytoplasmic antibodies with antigen specificity for proteinase 3 (PR3‐ANCA) were detected supporting the diagnosis of Wegener granulomatosis. Further evaluation showed involvement of the eyes and kidneys. The ulcer rapidly healed under treatment with cyclophosphamide and corticosteroids.