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Meta‐analysis of published data on incompletely excised basal cell carcinomas of the ear and nose with introduction of an innovative treatment strategy
Author(s) -
Rogalski Christina,
Kauer Friederike,
Simon Jan Christoph,
Paasch Uwe
Publication year - 2007
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2007.06197.x
Subject(s) - nose , medicine , surgery , basal cell , randomized controlled trial , basal cell carcinoma , stage (stratigraphy) , basal (medicine) , patient data , pathology , biology , computer science , database , paleontology , insulin
Summary Background : Auricular/nasal basal cell carcinomas (BCC) often require more surgical procedures than BCCs at other sites. Methods : A meta‐analysis of incompletely excised BCCs compares those on the ear and nose to other sites. The combination of photodynamic diagnostics (PDD) and fresh‐frozen sections is compared to multi‐stage excisions; in each case, the tissue margins were histographically controlled. Results : The relative risk of an incomplete excision of a BCC on the ear/nose is 2.5 fold higher than on the rest of the body. The combination of PDD and micrographic surgery with fresh‐frozen sections reduces the length of stay by 42.86 % from median 14 d to 8 d as well as increasing the revenue per patient per day by 41.9 % from 320.61 € to 454.95 € with nearly a comparable rate of recurrences after one year. Conclusions : PDD in combination with single‐stage surgery is an equivalent therapy with few side effects and conforming to guidelines. It takes into account both quality assurance and patient preferences. Multicenter, randomized trials seem desirable.