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New insights into the molecular biology and targeted therapy of cutaneous T‐cell lymphomas
Author(s) -
Klemke ClausDetlev,
Goerdt Sergij,
Schrama David,
Becker Jürgen C.
Publication year - 2006
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2006.05982.x
Subject(s) - targeted therapy , medicine , computational biology , cancer research , biology , cancer
Summary Cutaneous T‐cell lymphoma is an extra‐nodal non‐Hodgkin lymphoma of mature T cells.These tumor cells home to and persist in the skin,producing a broad spectrum of clinical entities. Recent results of basic research on tumor biology and tumor immunology as well as molecular genetics of cutaneous T‐cell lymphoma have fostered the development of new therapeutic approaches. Several clinical trials testing these targeted therapies have shown encouraging results. This article provides an overview of recent research developments and therapeutic strategies for cutaneous T‐cell lymphoma.