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Effects of aging on RANKL and OPG levels in gingival crevicular fluid during orthodontic tooth movement
Author(s) -
Kawasaki K,
Takahashi T,
Yamaguchi M,
Kasai K
Publication year - 2006
Publication title -
orthodontics and craniofacial research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 55
eISSN - 1601-6343
pISSN - 1601-6335
DOI - 10.1111/j.1601-6343.2006.00368.x
Subject(s) - rankl , osteoprotegerin , medicine , dentistry , juvenile , orthodontics , endocrinology , activator (genetics) , receptor , biology , genetics
Structured Abstract Authors – Kawasaki K, Takahashi T, Yamaguchi M, Kasai K Objectives – To compare the levels of the receptor activator of NF k B ligand (RANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement in juvenile and adult patients. Design – Fifteen juveniles and 15 adults served as subjects. GCF was collected from the distal cervical margins of the experimental and control teeth at 0, 1, 24, and 168 h after application of a retracting force. Enzyme‐linked immunosorbent assay kits were used to determine RANKL and OPG levels in the GCF samples. Results – The amount of tooth movement for juveniles was larger than for adults after 168 h. Further, after 24 h RANKL levels were increased and those of OPG decreased in GCF samples from the compression side during orthodontic tooth movement in both juveniles and adults. The RANKL/OPG ratio in GCF from adult patients was lower than that in the juvenile patient samples. Conclusion – Our results suggest that the age‐related decrease in amount of tooth movement may be related to a decrease in RANKL/OPG ratio in GCF during the early stages of orthodontic tooth movement.