Open AccessGenomic Evolution of the Distal Mhc Class I Region on Mouse Chr 17
Author(s) -
Yoshino Masayasu,
Xiao Hong,
Jones Elsy P.,
Kumanovics Attila,
Amadou Claire,
Lindahl Kirsten Fischer
Publication year - 1997
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1997.00141.x
Subject(s) - biology , contig , synteny , breakpoint , genetics , gene , homology (biology) , mhc class i , mhc class ii , chromosome , major histocompatibility complex , genome
A 5–Mb YAC contig, partly supplemented with BAC contigs, was created from the distal Mhc class I region on mouse Chr 17. The gene order of Znf 173‐Tctex5‐Mog‐D17Tu42‐D17Lrh 89 is conserved between mouse and human but not the physicdl distance, supporting the independent expansion of Mhc class I genes in the so‐called accordion model of Mhc evolution. The distal H2‐M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t ‐inversion. The H2‐M region is rich in L1 repeats, implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.