Open AccessThe HSR Chromosome 1 in the House Mouse, Mus Musculus , from Regions of the Urals Polluted by Mutagens
Author(s) -
Gileva Emily A.
Publication year - 1996
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1996.00061.x
Subject(s) - biology , house mouse , house mice , chromosome , genetics , laboratory mouse , zoology , gene
The incidence of the HSR chromosome I was examined in Mus musculus musculus , from 12 localities of the Middle and South Urals and Northwestern Siberia. The HSR chromosome was found in 7 localities, its frequency varying from 5 up to 18%. The HSR incidence was shown to correlate with the mean pooled frequency of aneuploidy and polyploidy in bone marrow, but not with the mean proportion of cells carrying structural chromosome aberrations. In mice heterozygous for HSR the rate of aneuploidy and polyploidy was significantly higher than in animals with standard karyotype, on average by a factor 2.35. HSRs tend to be more abundant in localities adjacent to sites of radiation incidents with contamination mainly by 90 Sr.