Open AccessA Female Sterile Embryonic Lethal in the Maternally Haplo‐Insufficient 21 B8.C1‐21 C8.D1 Genomic Region of Drosophila melanogaster
Author(s) -
Chandrashekaran Shanti
Publication year - 1995
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1995.00121.x
Subject(s) - biology , drosophila melanogaster , genetics , embryonic stem cell , polytene chromosome , embryogenesis , gene , mutant , allele , chromosome , lethal allele , drosophilidae , genetic analysis
Maternal hemizygosity of the 21 B8.C1‐21 C8.D1 aristaless region of chromosome 2L of Drosophila melanogaster leads to high levels of embryonic mortality from the cross of Df(2L) al/+ females ×+/+ males. The 21 B8.C1‐21 C8.D1 polytene section therefore carries maternally active gene(s) essential for embryogenesis. Selective screening for female sterile mutants against Df(2L) al yielded six alleles of a new female sterile embryonic lethal. This confirms the assumption that genomic regions that are maternally haplo‐insufficient for normal embryogenesis house maternally active gene(s). It also demonstrates that mutational analysis of similar genomic regions can identify maternally acting embryonic lethal loci which escaped detection in spite of extensive screening experiments.