Open AccessAnticlastogenic Effects of Aevitum Intake in a Group of Chemical Industry Workers
Author(s) -
Mierauskienė J.,
Lekevičius R.,
Lazutka J. R.
Publication year - 1993
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1993.00201.x
Subject(s) - biology , group (periodic table) , chemical industry , toxicology , engineering , organic chemistry , chemistry , environmental engineering
The incidence of chromosome aberrations (CAs) was investigated in cultured lymphocytes of 109 styrene‐, formaldehyde‐, and phenol‐exposed workers in comparison with 64 controls. There was a marked increase in the incidence of the structural chromosome aberrations in the first mitotic division metaphases of occupationally exposed workers (3.59 ± 0.26 CAs/100 cells vs 1.47 ± 0.14 in controls (P 0.01). 22 occupationally‐exposed workers were selected for the trial including 1‐month administration of a drug Aevitum (100,000 U of retinol palmitate plus 0.1 g of α‐tocopherol acetate dissolved in 0.2 ml of oil) at a daily dose of 1–2 capsules for 5 days a week. The frequency of chromosome aberrations before, after the administration of a cumulative Aevitum dose of 2.0, 4.0 and 8.0 ml, and 6 weeks after the cessation of vitamine intake was 5.68 ± 0.63, 4.33 ± 0.45, 2.67 ± 0.34, 2.00 ± 0.25, and 2.64 ± 0.21 per 100 cells, respectively. Thus, Aevitum was found to cause a significant decrease in occupationally‐induced chromosome damage in human lymphocytes.