Open AccessEffect of chlorpromazine hydrochloride on the formation of micronuclei in the bone marrow of mice exposed to gamma radiation
Author(s) -
JAGETIA GANESH CHANDRA
Publication year - 1992
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1992.tb00561.x
Subject(s) - micronucleus test , bone marrow , chlorpromazine , micronucleus , biology , hydrochloride , pharmacology , drug , radiation dose , toxicology , medicine , immunology , nuclear medicine , toxicity , biochemistry
The frequency of micronuclei was determined in the bone marrow of female BALB/c mice treated with various doses of chlorpromazine hydrochloride (CPZ) before exposure to 4.0 Gy of gamma radiation at 24 h post‐exposure. In animals treated with CPZ alone, the frequency of micronuclei increased with the increase in drug dose. A similar pattern was observed when the mice were exposed to 4.0 Gy radiation after CPZ treatment. The dose response curves thus obtained for the CPZ treated and CPZ + irradiated groups were linear quadratic.