Open AccessPutative fragile sites in the horse karyotype
Author(s) -
RØNNE MOGENS
Publication year - 1992
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1992.tb00166.x
Subject(s) - biology , karyotype , bromodeoxyuridine , chromosomal fragile site , genetics , microbiology and biotechnology , chromosome , gene , cell growth
After fluorouracil/5‐bromodeoxyuridine synchronization and subsequent FPG‐staining, the karyotype of 15 phenotypically normal horses displayed several breaks and gaps. Twelve bands 124, 4p12, 8q23, 11p12, 16q21, 17q21, 23q31, 23q32, Xp21, Xq22, Xq25 and Xq27 showed relatively frequent fragility. After thymidine/cytidine synchronization and subsequent GWL‐banding the same horses display karyotypes without any fragility. Hence it is suggested that the above listed bands harbour folate and/or 5‐bromo‐deoxyuridine sensitive fragile sites.