Open AccessThe porcine PGD gene is preferentially lost from chromosome 6 in pig × rodent somatic cell hybrids
Author(s) -
THOMSEN PREBEN D.,
BOSMA ANNEKE A.,
KAUFMANN UWE,
HARBITZ INGRID
Publication year - 1991
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1991.tb00347.x
Subject(s) - biology , somatic cell , gene , genetics , microbiology and biotechnology , rodent , chromosome , hybrid , cloning (programming) , chromosome instability , botany , ecology , computer science , programming language
The 6‐phosphogluconate dehydrogenase (PGD) and glucose phosphate isomerase (GPI) genes are both located on chromosome 6 in the pig (Sus scrofa domestica). Nonetheless, the PGD gene was absent in a total of 17 GPI‐positive cell lines found in three independently derived panels of pig × rodent somatic cell hybrids. In most of these cell lines we found an apparently normal pig chromosome 6 at cytogenetic analysis. These results suggest instability of the porcine PGD gene region in interspecies hybrid cells.