Open AccessDown's syndrome: increased enzymatic antioxidative defense is accompanied by decreased superoxide anion generation in blood
Author(s) -
KλZIORA J.,
BŁASZCZYK J.,
SIBIŃSKA E.,
BARTOSZ G.
Publication year - 1990
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1990.tb00699.x
Subject(s) - superoxide , zymosan , enzyme , biology , immune system , immunology , stimulation , superoxide dismutase , biochemistry , endocrinology , medicine , in vitro
Whole blood leukocytes of DS patients were found to produce less superoxide radical anion than in healthy controls, especially without stimulation with zymosan. This decreased superoxide generation may contribute to the immune system deficiency reported for DS.