Open AccessIn situ hybridization localizes the human type II alpha 1 collagen gene (COL2A1) to 12q13
Author(s) -
ARHEDEN KRISTINA,
MANDAHL NILS,
HEIM SVERRE,
MITELMAN FELIX
Publication year - 1989
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1989.tb00437.x
Subject(s) - biology , gene , chromosome , in situ hybridization , alpha (finance) , chromosome band , in situ , genetics , gene mapping , microbiology and biotechnology , gene expression , medicine , construct validity , physics , nursing , meteorology , patient satisfaction
We have, using in situ hybridization technique, localized the human type II alpha 1 collagen gene ( COL2A1 ) to chromosome band 12q13. The gene had previously been assigned to either 12q 13.1–13.2 or 12q14.3. Since the chromosome segment 12q13–15 has been shown to be rearranged in several benign and malignant human neoplasms, the exact band localization of COL2A1 within this region makes it a useful marker for the molecular analysis of these tumors.