Open AccessConstitutional C‐band polymorphism in lymphocytes from patients with chronic myeloid leukemia
Author(s) -
KRISTOFFERSSON ULF,
BERNHEIM ALAN,
BERGER ROLAND,
NILSSON BO,
HEIM SVERRE,
MANDAHL NILS,
MITELMAN FELIX
Publication year - 1989
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1989.tb00434.x
Subject(s) - biology , heterochromatin , myeloid leukemia , constitutive heterochromatin , genetics , chromosome , gene , polymorphism (computer science) , microbiology and biotechnology , cancer research , allele
The C‐band heterochromatin polymorphism of chromosomes 1,9, and 16 was studied in lymphocytes from 53 patients with Ph 1 ‐positive chronic myeloid leukemia (CML) and 183 control persons. The patients had significantly larger heterochromatic blocks on chromosome 16 (p<0.01) and fewer partial inversions of chromosome 9 (p<0.05) than the control persons, whereas no differences were found for the symmetry/asymmetry pattern. We suggest that the increased constitutive heterochromatin regions may, via sister chromosome exchange, facilitate homo‐ or hemizygotization of genes which favor neoplasia development and/or progression.