Open AccessNormal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma
Author(s) -
JOHANSSON BERTIL,
MERTENS FREDRIK,
HEIM SVERRE,
KRISTOFFERSSON ULF,
MANDAHL NILS,
OLSSON HÅKAN,
MITELMAN FELIX
Publication year - 1988
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1988.tb00365.x
Subject(s) - biology , chromatid , chromosome instability , chromosome , lymphoma , incidence (geometry) , non hodgkin's lymphoma , hodgkin lymphoma , cancer research , genetics , pathology , medicine , immunology , physics , gene , optics
The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P<0.05) increase with age in the number of aberrant cells.