Open AccessUnbalanced Robertsonian translocations in canine lymphocytes and bone marrow cells in vitro
Author(s) -
WELLING JUKKA,
STRANDSTROM HELENA
Publication year - 1988
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1988.tb00355.x
Subject(s) - biology , bone marrow , chromosomal translocation , mitosis , in vitro , immunology , pathology , microbiology and biotechnology , genetics , medicine , gene
Cytogenetic analyses of lymphocytes and bone marrow cells were performed on 10 haematologically healthy dogs. A wide range of mitoses with unbalanced Robertsonian translocations (1–2 per cell) was encountered in both stimulated lymphocytes (frequency 3±1 %) and methotrexatesynchronized bone marrow cells (frequency 5±2 %) but not in bone marrow cells prepared with the direct method.