Open AccessRelative fertility and mutation rate in neurofibromatosis
Author(s) -
SAMUELSSON BIRGITTA,
ÅKESSON HANS OLOF
Publication year - 1988
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1988.tb00297.x
Subject(s) - fertility , biology , neurofibromatosis , mutation rate , mutation , selection (genetic algorithm) , genetics , heritability , population , total fertility rate , demography , research methodology , family planning , gene , artificial intelligence , sociology , computer science
The epidemiology and genetics of neurofibromatosis were described in a previously published population study. The present paper supplements that investigation with an estimation of mutation rate and relative fertility, or selection disadvantage, of neurofibromatosis. The relative fertility was estimated to be 78 % and the mutation rate was found to be somewhere between 2.4 and 4.3 × 10‐ 5 , The results verify that this common disease has one of the highest mutation frequencies known in man.