Open AccessDistribution of structural chromosome aberrations in skin fibroblasts from patients with benign mesenchymal tumors
Author(s) -
MERTENS FREDRIK,
JOHANSSON BERTIL
Publication year - 1988
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1988.tb00192.x
Subject(s) - mesenchymal stem cell , biology , chromosome , pathology , mesenchymal tumor , genetics , gene , immunohistochemistry , immunology , medicine
The distribution of structural chromosomal aberrations was studied in cultured skin fibroblasts from 14 untreated patients with benign mesenchymal tumors, and 39 controls. Among the tumor patients, 100 aberrations could be localized to specific bands, with the following 9 bands appearing as hot spots: lp32, 2q23, 3p21, 4q31, 6q21, 7q22, 7q32, 13q22, and 15q22. Five of these coincided with the 21 hot spots detected in the control group. Only one, 2q23, is also known to be involved in primary chromosome rearrangements in benign mesenchymal neoplasms. The genesis of the characteristic rearrangements in such tumors is therefore not facilitated by intrinsic chromosome fragility at these specific bands.