Open AccessBreakprone chromosome bands in lymphocytes from sarcoma patients do not coincide with bands involved in primary sarcoma‐associated chromosome rearrangements
Author(s) -
MERTENS FREDRIK,
JOHANSSON BERTIL
Publication year - 1988
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1988.tb00191.x
Subject(s) - biology , sarcoma , chromosome , breakpoint , chromosomal fragile site , chromosomal translocation , genetics , karyotype , chromosomal rearrangement , microbiology and biotechnology , pathology , gene , medicine
The localization of breakpoints in spontaneous chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in lymphocytes from 28 untreated patients with musculoskeletal sarcoma, and 30 controls. One hundred and two breakpoints in the sarcoma group and 117 in the control group could be assigned to particular chromosome bands. Assuming a Poisson distribution, the aberrations among the controls did not deviate significantly from the expected values, whereas the distribution among the sarcoma patients was nonrandom (p<0.01). In the sarcoma group, chromosome aberrations preferentially involved bands 4q21, 5q31, 7q22, 9q11, and 10q24 and, in the control group, 2q21, 6q23, 7q22, and 14q24. When comparing these hot spots with literature data on structural abnormalities in sarcomas, we found that none of them coincided with bands involved in primary rearrangements in sarcoma cells. Thus, bands involved in primary chromosome abnormalities are not constitutionally prone to breakage and rearrangements. No association was found between the hot spots in this series and known rare or common fragile sites.