Open AccessCytogenetic studies of childhood non‐Hodgkin lymphomas
Author(s) -
KRISTOFFERSSON ULF,
HEIM SVERRE,
HELDRUP JESPER,
ÅKERMAN MÅNS,
GARWICZ STANISLAW,
MITELMAN FELIX
Publication year - 1985
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1985.tb00485.x
Subject(s) - biology , karyotype , lymphoma , giemsa stain , ploidy , pathology , lymphoblastic lymphoma , cytogenetics , malignant histiocytosis , immunology , chromosome , genetics , t cell , medicine , histiocyte , immune system , gene
Cytogenetic examination by means of the Giemsa banding technique was performed on 11 biopsies from six children with non‐Hodgkin lymphoma: three lymphoblastic T‐cell lymphomas, two lymphoblastic B‐cell Burkitt‐like lymphomas, and one malignant histiocytosis. All patients were males, aged 1–13 years. At diagnosis 4 patients displayed clonal karyotypic changes. Two patients had at diagnosis only metaphases with a normal diploid karyotype; in one of these cases repeated investigations during the course of the disease demonstrated evolution to an abnormal karyotype. All patients with abnormalities had different karyotypic changes. In the total material the following clonal aberrations were identified: i(1q), t(1; 17) (p36; q21), t(2; 5) (p21; q35), del(4) (q24), del(9) (q22), t(13; ?) (q34; ?), t(14; 18)(q32; q21), t(17; ?) (p13; ?), and +20.