Open AccessA family with Charcot‐Marie‐Tooth's disease, showing a probable X‐linked incompletely dominant inheritance
Author(s) -
ISELIUS LENNART,
GRIMBY LENNART
Publication year - 1982
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1982.tb00723.x
Subject(s) - biology , inheritance (genetic algorithm) , genetics , x linked recessive inheritance , tooth disease , genetic linkage , linkage (software) , chinese family , x chromosome , gene
Charcot‐Marie‐Tooth's disease (CMT) or peroneal muscular atrophy may show an autosomal dominant, autosomal recessive, X‐linked recessive and X‐linked dominant inheritance (S kre 1974). Xlinked dominant inheritance seems to be very rare (B ecker 1966), although W itkowski and P rokop (1976) have suggested that there is an overlap between X‐linked recessive and X‐linked dominant inheritance, since both types of inheritance have been observed in the same family. A linkage study on a family with X‐linked partially dominant CMT has been reported ( de W eerdt et al. 1976; de W eerdt 1978), showing no evidence of linkage to Xg. F ryns and van den B erghe (1980) have reported the clinical findings in a similar family. We wish to report a family in which CMT appeared to segregate as an X‐linked incomplete dominant.