Open AccessChromosomal patterns in a benign human neoplasm, the mixed salivary gland tumour
Author(s) -
MARK JOACHIM,
DAHLENFORS RIGMOR,
EKEDAHL CLAES,
STENMAN GÖRAN
Publication year - 1982
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1982.tb00044.x
Subject(s) - chromosomal translocation , biology , salivary gland , pleomorphic adenoma , karyotype , in vitro , pathology , chromosome , genetics , gene , medicine , biochemistry
In an in vitro system the chromosomes were studied by banding methods in 30 mixed salivary gland tumours. Among the pleomorphic adenomas 40 % had an abnormal stemline. A common denominator for the majority of these adenomas was a translocation or, rarely, a deletion of the segment 8q12‐8q22; most of the adenomas in this group showed, in fact, a specific translocation, namely t(3;8)(p21;q12). Other, less common professional alternatives were t(9;12) (p13‐22; q13‐15), found in two cases, and ins (15;5) (q22; q14q31), seen in only one tumour. Most adenomas with a normal stemline contained one or more variant cells. Detailed studies of these cells indicated that, as a rule, only variant cells with structural deviations, in particular certain types of reciprocal translocations, were of importance for the development of an abnormal stemline.