Open AccessMicronuclei and chromosome aberrations in bone marrow cells and lymphocytes of humans exposed mainly to petroleum vapors
Author(s) -
HÖGSTEDT B.,
GULLBERG B.,
MARKVENDEL E.,
MITELMAN F.,
SKERFVING S.
Publication year - 1981
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1981.tb01751.x
Subject(s) - micronucleus test , bone marrow , biology , micronucleus , peripheral blood , chromosome , arsenic , immunology , microbiology and biotechnology , pathology , genetics , chemistry , toxicity , medicine , gene , organic chemistry
Several cytogenetic parameters, i.e. chromosome aberrations in bone marrow cells and in peripheral lymphocytes as well as micronuclei in erythropoietic bone marrow cells, were studied in 16 tank cleaners exposed to organic solvents and other petroleum products and sediments containing heavy metals, such as lead, mercury, arsenic and cadmium. Micronuclei and chromosome breaks in peripheral blood lymphocytes proved significantly more common in tank cleaners than in controls. The data indicated an exposure‐connected relationship, suggesting that assessment of micronuclei in bone marrow cells might be a useful method for detecting cytogenetic effects in humans chronically exposed to chemical agents. In this respect both erythroblasts and polychromatic erythrocytes could be studied.