Open AccessChromosome segregation in lymphocyte hybrids
Author(s) -
SCHRöDER J.,
SUTINEN M.L.,
SUOMALAINEN H. A.
Publication year - 1981
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1981.tb01735.x
Subject(s) - biology , hybrid , lymphocyte , chromosome , microbiology and biotechnology , ploidy , genetics , gene , botany
Chromosome segregation was studied in mouse/human and mouse/mouse T‐lymphocyte hybrids, and in mouse/human, mouse/rabbit and mouse/rat B‐lymphocyte hybrids. Chromosome loss was not random, it was moderate in mouse/mouse and mouse/rat lymphocyte hybrids, but extensive in mouse/human and mouse/rabbit lymphocyte hybrids. Chromosomes carrying genes coding for T‐cell differentiation markers were preferentially retained in interspecific as well as intraspecific T‐cell hybrids. In mouse/rabbit B‐lymphocyte hybrids, only two of 750 cells from five independent mass cultures contained any rabbit chromosomes.