Open AccessInterpretation of a marker chromosome 17p in multiple myeloma
Author(s) -
SHABTAI F.,
HALBRECHT I.
Publication year - 1981
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1981.tb01322.x
Subject(s) - biology , chromosomal translocation , chromosome , marker chromosome , multiple myeloma , genetics , secondary constriction , long arm , karyotype , microbiology and biotechnology , gene , immunology
Sixteen patients with multiple myeloma (MM) have been studied cytogenetically. Chromosome 14 was the chromosome most often involved in structural aberrations. Chromosome 17 was involved in numerical aberrations and its short arm was frequently damaged at p12, giving the chromosome a satellited appearance, similar to that found in healthy people with a familial heteromorphic 17p. In our opinion the change in the 17p marker in MM represents a constriction (site of viral modification?) and is not a translocation.