Open AccessAberrations of chromosome No. 1 in blastic phase of chronic myeloid leukemia
Author(s) -
ALIMENA G.,
DALLAPICCOLA B.,
MITELMAN F.,
MONTUORO A.
Publication year - 1980
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1980.tb01679.x
Subject(s) - chromosomal translocation , trisomy , biology , myeloid leukemia , chromosome , karyotype , philadelphia chromosome , genetics , aneuploidy , chromosome 3 , cancer research , chromosome 13 , medicine , gene
Aberrations of chromosome No. 1 were detected at the time of blastic crisis in 7 patients with Ph 1 ‐positive chronic myeloid leukemia (CML). Two patients had trisomy 1; trisomy for a long arm segment of chromosome No. 1 was present in 2 patients; trisomy for a short arm segment occurred in 2 patients; and one patient had an apparently balanced translocation affecting chromosome No. 1. All patients with extra material of chromosome No. 1 were trisomic for the region 1p22–1pter or 1q21–1qter. A survey of abnormalities of chromosome No. 1 in this series and in other patients with CML previously reported show, in all patients, a relative increase or decrease of genetic material of two specific regions: 1q32–1q42 and 1p36–1pter.