Open AccessKaryotypes in six leukaemia cell lines derived from patients with ALL
Author(s) -
SUOMALAINEN HELI A.,
ANDERSSON LEIF C.,
SCHRÖDER JIM
Publication year - 1980
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1980.tb01046.x
Subject(s) - isochromosome , karyotype , biology , chromosomal translocation , cell culture , lymphoma , cytogenetics , virology , phenotype , cancer research , microbiology and biotechnology , genetics , immunology , chromosome , gene
Karyotypes were studied in six continuous Epstein‐Barr virus (EBV)‐negative leukaemia cell lines. The lines have been established from patients with acute lymphocytic leukaemia (ALL) and express a T‐cell or a non‐T/non‐B cell phenotype. Five of the six lines have developed tetraploidy in all or in some of the cells. Two lines showed a 6q‐marker and one line an isochromosome 7q; both aberrations have previously been described in ALL. Another line had a reciprocal 8;14 translocation typical for Burkitt's lymphoma. Additional changes were observed in all lines.