Open AccessNormal stem cell proliferation and cell depletion after X‐irradiation of spermatogonia of inbred and hybrid mice
Author(s) -
VALENTIN KATHARINA
Publication year - 1978
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1978.tb01611.x
Subject(s) - biology , inbred strain , hybrid , andrology , significant difference , genetics , medicine , botany , gene
Male mice from inbred CBA, inbred A/Jax and F 1 hybrids from the two reciprocal crosses between CBA and A/Jax strains were investigated. Counts of the number of type A spermatogonia in the seminiferous epithelium were made in control animals and males irradiated with 276 R X‐rays. All four control groups seem to contain the same numbers of undifferentiated type A spermatogonia. However, there is a significant difference between pure strains and hybrids in the rate of increase for those cells which have already entered the proliferation phase. The F 1 hybrids produce higher final numbers of differentiated spermatogonia. The course of cell depletion in the four separate groups after X‐irradiation are compared by a regression analysis of the surviving fraction of type A spermatogonia. No difference in spermatogonial sensitivity to the irradiation could be detected during day 1 to 4 after treatment. Scoring of a limited material from the successive three days does not indicate any rapid increase in the number of type A spermatogonia during this period.